3-Bromo-4-oxo-4-phenylbutanoic acid → HCID 86739401, compound

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Reaction Steps

A solution of 3-benzoyl-3-bromo propionic acid (6.4 g, 0.025 moles) in methanol (40 ml) was mixed with a solution of 1,5-dimethyl-3,4,5,6-tetrahydro-s-triazin-2(1H)thione (3.625 g, 0.025 mole) in the same solvent (100 ml). After 2 hours at room temperature the solvent was evaporated to give a foam which was crystallised from isopropanol to give 7-carboxymethyl-1,3-dimethyl-6-hydroxy-6-phenyl-3,4,5,7-tetrahydro-2H-thiazolo[3,2-a]-s-triazinium bromide isopropanolate (10.05 g,), m.p. 154°-155° C. (decomposition).

Provenance & Evidence