反应详情

A suspension of 5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine (543 g, 2 mmoles) in methanol (20 ml) was treated with hydrogen chloride-methanol. After the solvent was distilled off, the residue was crystallized from chloroform ether. Then, the crystals thus obtained were washed with ether and dried to obtain 550 mg of the desired product (89.3%, colorless crystals).

1. distillationAfter the solvent was distilled off
2. customthe residue was crystallized from chloroform ether
3. customThen, the crystals thus obtained
4. washwere washed with ether
5. customdried