Propargyl bromide → HCID 20461197, compound

HRID 543901Notes

Reaction equation

HRID 543901 reaction equation
[NH2:1][CH:2]([CH:20]([CH3:22])[CH3:21])[C:3]([O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]=1)=[O:4].[CH2:23](Br)[C:24]#[CH:25]>>[CH2:25]([NH:1][CH:2]([CH:20]([CH3:22])[CH3:21])[C:3]([O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]=1)=[O:4])[C:24]#[CH:23]

Participants

3

Reactant 2

HCID 7842Propargyl bromideHCID 12926384HCID 12926384, compound

Product 1

HCID 20461197HCID 20461197, compound

Procedure

Following the procedure of Example 2, (6-phenoxy-2-pyridyl)methyl 2-amino-3-methylbutanoate and 2-propyn-1-yl bromide are reacted, resulting in a mixture of two end products, which are separated to give (6-phenoxy-2-pyridyl)methyl 2-[N-(2-propynyl)amino]-3-methylbutanoate and (6-phenoxy-2-pyridyl)methyl 2-[N,N-(di-2-propynyl)amino]-3-methylbutanoate.

Workup

  1. customare reacted
  2. customresulting in a mixture of two end products, which
  3. customare separated

Sources & evidence

ORD record
ord-029349bd63114ef5ac99192d9c2aa87b
Source dataset
uspto-grants-1984_05
Patent number
US04447613

Reaction notes

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