N-Formyl-DL-valine → HCID 20461200, compound

HRID 543903Notes

Reaction equation

HRID 543903 reaction equation
[F:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][C:7]2[N:12]=[C:11]([CH2:13]Br)[CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[CH:17]([NH:19][CH:20]([CH:24]([CH3:26])[CH3:25])[C:21]([OH:23])=[O:22])=[O:18]>>[F:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][C:7]2[N:12]=[C:11]([CH2:13][C:20]([NH:19][CH:17]=[O:18])([CH:24]([CH3:26])[CH3:25])[C:21]([OH:23])=[O:22])[CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 100123N-Formyl-DL-valineHCID 20461199HCID 20461199, compound

Product 1

HCID 20461200HCID 20461200, compound

Procedure

Following the procedure of Example 1, [6-(4-fluorophenoxy)-2-pyridyl]methyl bromide can be reacted with 2-(N-formylamino)-3-methyl-butanoic acid to give [6-(4-fluorophenoxy)-2-pyridyl]methyl 2-(N-formylamino)-3-methyl-butanoic acid, which is further reacted with methanol, yielding [6-4-fluorophenoxy)-2-pyridyl]methyl 2-amino-3-methylbutanoate.

Sources & evidence

ORD record
ord-e906202dcfaa40f2989fc01e778c4335
Source dataset
uspto-grants-1984_05
Patent number
US04447613

Reaction notes

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