Phosgene → HCID 20461183, compound

HRID 543904Notes

Reaction equation

HRID 543904 reaction equation
[CH:1]([NH:4][C@H:5]([C:9]([OH:11])=[O:10])[CH:6]([CH3:8])[CH3:7])([CH3:3])[CH3:2].[C:12](Cl)(Cl)=[O:13]>O1CCOCC1>[CH:1]([N:4]1[CH:5]([CH:6]([CH3:7])[CH3:8])[C:9](=[O:11])[O:10][C:12]1=[O:13])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 6371PhosgeneHCID 13778607HCID 13778607, compound

Product 1

HCID 20461183HCID 20461183, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Finely ground N-isopropyl valine (31 mmol) in 150 ml dioxane is heated to 38°-40° and excess carbonyl chloride is slowly passed in over 4-5 hours. Dry air is then passed through the reaction for 18 hours, after which the dioxane is removed at 40° (20 mm) to yield 3,4-diisopropyl-oxazolidine-2,5-dione.

Workup

  1. customis slowly passed in over 4-5 hours
  2. customDry air
  3. customis then passed through the reaction for 18 hours
  4. customafter which the dioxane is removed at 40° (20 mm)

Sources & evidence

ORD record
ord-5f0c46b4a4fe443486b68654e770b3e3
Source dataset
uspto-grants-1984_05
Patent number
US04447613

Reaction notes

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