Acetic Anhydride → 2-(2-Formamidothiazol-4-yl)-2-ethoxyiminoacetic acid

HRID 543931Notes

Reaction equation

HRID 543931 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH2:13][CH3:14])[C:8]([OH:10])=[O:9])[N:6]=1.[C:15](OC(=O)C)(=[O:17])C>C(O)=O>[CH:15]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH2:13][CH3:14])[C:8]([OH:10])=[O:9])[N:6]=1)=[O:17]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 534242352-(2-Amino-4-thiazolyl)-2-ethoxyiminoacetic acid

Product 1

HCID 544580772-(2-Formamidothiazol-4-yl)-2-ethoxyiminoacetic acidYield 87.7%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

2-(2-Aminothiazol-4-yl)-2-ethoxyiminoacetic acid (syn isomer, 100 g.), formic acid (85.5 g.) and acetic anhydride (190.1 g.) were treated in a similar manner to that of Example F-(5) to give 2-(2-formamidothiazol-4-yl)-2-ethoxyiminoacetic acid (syn isomer, 99.1 g.).

Sources & evidence

ORD record
ord-8ea0c9c6cb944f35b5d0e76b44192915
Source dataset
uspto-grants-1984_05
Patent number
US04447430

Reaction notes

Loading…