反应详情

A mixture of 2 g of ethyl 2,2-dimethyl-3-ethoxycarbonyl-1-cyano-cyclopropane-1-carboxylate (prepared as in U.S. Pat. No. 3,397,223) and 4.71 g of 10% ethanolic potassium hydroxide was stirred under an inert atmosphere for 15 hours and the ethanol was then evaporated under reduced pressure. The residue was washed with ether and was then taken up in ether. The pH of the solution was adjusted to 3 by addition of dilute sulfuric acid and the decanted ether phase was washed with water, dried and evaporated to dryness under reduced pressure to obtain 1.6 g of 2,2-dimethyl-3-ethoxycarbonyl-1-cyano-cyclopropane-1-carboxylic acid with a melting point of ≃130° C. (decomposition).

1. customprepared as in U.S
2. customthe ethanol was then evaporated under reduced pressure
3. washThe residue was washed with ether
4. additionThe pH of the solution was adjusted to 3 by addition of dilute sulfuric acid
5. washthe decanted ether phase was washed with water
6. customdried
7. customevaporated to dryness under reduced pressure