Ammonia → HCID 70478397, compound

HRID 544110Notes

Reaction equation

HRID 544110 reaction equation
C([O:3][C:4](=O)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]2[NH:15][CH:16]=[CH:17][N:18]=2)=[CH:9][CH:8]=1)C.[NH3:20]>C(O)C>[NH:18]1[CH:17]=[CH:16][N:15]=[C:14]1[CH2:13][C:10]1[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([NH2:20])=[O:3])=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 70456159HCID 70456159, compound

Product 1

HCID 70478397HCID 70478397, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4-(1-imidazolylmethyl)phenoxyacetic acid ethyl ester (2.0 g) in ethanol (10 ml) and concentrated aqueous ammonia (SG 0.880) were heated under reflux for 2 hours and then evaporated. The residue was crystallised from a mixture of methanol and 2-butanone to give 4-(1-imidazolylmethyl)phenoxyacetamide (1.31 g) m.p. 173°-174° C. Found: C, 62.42, H, 5.76, N, 17.40. C12H13N3O2 requires: C, 62.32, H, 5.67, N, 18.17%.

Workup

  1. temperatureunder reflux for 2 hours
  2. customevaporated
  3. customThe residue was crystallised from a mixture of methanol and 2-butanone

Sources & evidence

ORD record
ord-72d984c618f34e62b04c256267698aea
Source dataset
uspto-grants-1984_05
Patent number
US04448781

Reaction notes

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