Potassium Hydroxide → HCID 70455698, compound

HRID 544114Notes

Reaction equation

HRID 544114 reaction equation
C([O:3][C:4](=[O:19])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][C:14]1[NH:15][CH:16]=[CH:17][N:18]=1)C.[OH-].[K+]>O>[NH:15]1[CH:16]=[CH:17][N:18]=[C:14]1[CH2:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[O:6][CH2:5][C:4]([OH:19])=[O:3]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 70478759HCID 70478759, compound

Product 1

HCID 70455698HCID 70455698, compoundYield 29.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-(1-Imidazolylmethyl)phenoxyacetic acid ethyl ester (1 g) was heated on a steam bath for 30 minutes in a solution of potassium hydroxide (0.5 g) in water (10 ml) and the solution was allowed to stand at room temperature for 18 hours. The solution was then evaporated to small volume and acidified to pH 5 with acetic acid. The solid was collected by filtration and crystallised from water to give 2-(1-imidazolylmethyl)phenoxyacetic acid (0.26 g), m.p. 213°-214° C. Found: C, 51.83, H, 5.24, N, 12.34. C12H12N2O3 requires: C, 62.05, H, 5.21, N, 12.06%.

Workup

  1. customThe solution was then evaporated to small volume
  2. filtrationThe solid was collected by filtration
  3. customcrystallised from water

Sources & evidence

ORD record
ord-e39dc25d989f4576bbe2693becb6b5e4
Source dataset
uspto-grants-1984_05
Patent number
US04448781

Reaction notes

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