HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl phosphite → Diethyl (3-methoxy-isoxazol-5-yl)-methane phosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl phosphite | HCID 31215 | — |
| Reactant | 3-(Chloromethyl)-1,2-oxazole | HCID 4913025 | — |
| Reactant | 5-(Chloromethyl)-3-methoxy-1,2-oxazole | HCID 10080543 | — |
| Product | Diethyl (3-methoxy-isoxazol-5-yl)-methane phosphonate | HCID 10538561 | 56.1% |
Reaction Steps
3.8 g 5-chloromethyl-3-methoxy-isoxazole and 6.0 g of triethylphosphite were stirred at 150° C. until complete conversion of the chloromethyl isoxazole (2-8 h). Kugelrohr destillation gave 3.6 g of diethyl (3-methoxy-isoxazol-5-yl)-methane phosphonate. Bp. 160°-165° C./0.3 mm Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05622953 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-f5490f4ffea645e6a1f3c4add4767df8 |
| Source note | uspto-grants-1997_04 |