Dimethyl Sulfate → HCID 20459812, compound

HRID 544200Notes

Reaction equation

HRID 544200 reaction equation
[C:1]([C:3]1[C:4](=[O:19])[NH:5][C:6](=[O:18])[N:7]([NH:9][C:10]2[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:17])[CH:8]=1)#[N:2].S(OC)(O[CH3:24])(=O)=O>[OH-].[Na+]>[C:1]([C:3]1[C:4](=[O:19])[N:5]([CH3:24])[C:6](=[O:18])[N:7]([NH:9][C:10]2[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:17])[CH:8]=1)#[N:2]

Participants

4

Reactant 2

HCID 6497Dimethyl SulfateHCID 20459820HCID 20459820, compound

Product 1

HCID 20459812HCID 20459812, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To a mixture of 5-cyano-1-(2,6-dimethylanilino)-2,4-pyrimidinedione (0.1 mol) and 80 ml of 5% sodium hydroxide solution, with stirring, is slowly added dimethyl sulfate (0.1 mol). The reaction mixture is stirred for about 2-4 hours and then filtered, washed with water and dried to yield 5-cyano-1-(2,6-dimethylanilino)-3-methyl-2,4-pyrimidinedione.

Workup

  1. stirringThe reaction mixture is stirred for about 2-4 hours
  2. filtrationfiltered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-82672ca338b74f02bf2f7c81fd2f9bdc
Source dataset
uspto-grants-1984_05
Patent number
US04448961

Reaction notes

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