Water → HCID 13326264, compound

HRID 544206Notes

Reaction equation

HRID 544206 reaction equation
C(CC([N:6]([C:11]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:18])[NH:7][C:8]([NH2:10])=[O:9])=O)#N.[OH2:19].[OH-].[Na+]>C(O)C>[NH2:6][C:11]1[N:7]([NH:6][C:11]2[C:12]([CH3:18])=[CH:13][CH:14]=[CH:15][C:16]=2[CH3:17])[C:8](=[O:9])[NH:10][C:13](=[O:19])[CH:12]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 20459805HCID 20459805, compound

Product 1

HCID 13326264HCID 13326264, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

One mole of the above phenylsemicarbazide is added to 400 ml of water, followed by the addition of 200 ml of ethanol. This mixture is heated to 85° and 165 ml of 10% sodium hydroxide is added. After 30 minutes the mixture is acidified to pH 5, cooled to RT, filtered and recrystallized in acetone/water, yielding 6-amino-1-(2,6-dimethylanilino)-2,4-pyrimidinedione.

Workup

  1. temperatureThis mixture is heated to 85°
  2. filtrationfiltered
  3. customrecrystallized in acetone/water

Sources & evidence

ORD record
ord-e05c56f2d56e471c82c207bc805ca897
Source dataset
uspto-grants-1984_05
Patent number
US04448961

Reaction notes

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