Ethanol → HCID 12733925, compound

Participants

Reaction Steps

Thionyl chloride (2.4 g) was added dropwise to a solution of 1-(2-hydroxyethyl)-6-fluoro-7-(4-acetyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (0.38 g) in ethanol (20 ml) under cooling with an ice-water bath, and the reaction mixture was refluxed for 5.5 hrs. The reaction mixture was evaporated to dryness, the residue was neutralized with aqueous potassium carbonate solution, and the solution was extracted with chloroform. After removing the chloroform, the residue was recrystallized from a mixture of methylene chloride and ethyl acetate to give 0.36 g of 1-(2-hydroxyethyl)-6-fluoro-7-(4-acetyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester.

Provenance & Evidence