反应详情

A mixture of 1-ethyl-7-chloro-1,4-dihydro-6-fluoro-4-oxoquinoline-3-carboxylic acid (0.80 g), 2-oxopiperazine (3.0 g) and 4 ml pyridine was heated for 18 hours. The reaction mixture was evaporated under vacuum, an aqueous solution of caustic soda was added to adjust the pH to 10, ice cooled and the undissolved matter was collected and washed with a small amount of an aqueous solution of NaOH. The filtered product was suspended in water, acidified with acetic acid, filtered and washed. The product obtained was dissolved in an aqueous solution of NaOH and acidified with acetic acid. The precipitate was filtered, washed and dried to obtain 0.32 g (32%) of 1-ethyl-1,4-dihydro-6-fluoro-7-(3-oxo-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid.

1. temperaturewas heated for 18 hours
2. customThe reaction mixture was evaporated under vacuum
3. additionan aqueous solution of caustic soda was added
4. temperaturecooled
5. customthe undissolved matter was collected
6. washwashed with a small amount of an aqueous solution of NaOH
7. filtrationfiltered
8. washwashed
9. customThe product obtained
10. filtrationThe precipitate was filtered
11. washwashed
12. customdried