反应详情

A mixture of 1-ethyl-6-chloro-7-(1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 1.7 g (0.005 mole), iodoethyl 1.6 g (0.01 mole), triethylamine 1.0 g (0.01 mole) and dimethylformamide (hereinafter DMF) 20 ml was heated at 90°-100° C. for 7 hours under stirring. After cooling, the reaction mixture was evaporated under vacuum. The residue was dissolved in CHCl3, washed with water, dried with anhydrous Na2SO4, and the solvent was distilled off. The residue was recrystallized from a mixed solvent of DMF and ethanol to obtain 0.4 g (22%) of 1-ethyl-6-chloro-7-(4-ethyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. Colorless needles.

1. temperaturewas heated at 90°-100° C. for 7 hours
2. temperatureAfter cooling
3. customthe reaction mixture was evaporated under vacuum
4. dissolutionThe residue was dissolved in CHCl3
5. washwashed with water
6. dry with materialdried with anhydrous Na2SO4
7. distillationthe solvent was distilled off
8. customThe residue was recrystallized from a mixed solvent of DMF and ethanol