2-Bromopyrimidine → 2,3-Piperazinedione, 1,4-bis((4-(2-pyrimidinylamino)phenyl)methyl)-

HRID 544245Notes

Reaction equation

HRID 544245 reaction equation
[NH2:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=3)[C:9](=[O:21])[C:8]2=[O:22])=[CH:4][CH:3]=1.Br[C:26]1[N:31]=[CH:30][CH:29]=[CH:28][N:27]=1>>[N:27]1[CH:28]=[CH:29][CH:30]=[N:31][C:26]=1[NH:20][C:17]1[CH:18]=[CH:19][C:14]([CH2:13][N:10]2[CH2:11][CH2:12][N:7]([CH2:6][C:5]3[CH:4]=[CH:3][C:2]([NH:1][C:26]4[N:31]=[CH:30][CH:29]=[CH:28][N:27]=4)=[CH:24][CH:23]=3)[C:8](=[O:22])[C:9]2=[O:21])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 783452-BromopyrimidineHCID 12752249HCID 12752249, compound

Product 1

HCID 30602522,3-Piperazinedione, 1,4-bis((4-(2-pyrimidinylamino)phenyl)methyl)-Yield 14.7%

Procedure

The 1,4-bis(4-aminobenzyl)-2,3-dioxopiperazine was reacted with 2-bromopyrimidine in the same manner as in Example 6-(1) to obtain 1,4-bis[4-(2-pyrimidinylamino)benzyl]-2,3-dioxopiperazine (14.7% yield).

Sources & evidence

ORD record
ord-9db95951ed8a49c88ef371a6568238c5
Source dataset
uspto-grants-1984_05
Patent number
US04448963

Reaction notes

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