3-Nitrobenzaldehyde → HCID 13108116, compound

Participants

Reaction Steps

In this example, 2.74 g of m-nitrobenzaldehyde, 2.09 g of methyl β-aminocrotonate and 5.50 g of acetoacetic acid-N-benzoyl-4-piperidinyl ester obtained in Reference Example 3 (hereinafter described) were added to 10 ml of THF, and stirring was effected at reflux for 33 hours. The reaction mixture was treated similarly as in Example 1 to obtain 2.84 g of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-(N-benzoyl-4-piperidinyl) ester-5-methyl ester [compound of the general formula (I) wherein R1 =R2 =R4 =CH3, ##STR14## wherein n=0, ##STR15## (yield: 30.2%)

Provenance & Evidence