HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diketene → HCID 20459841, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diketene | HCID 12661 | — |
| Reactant | 1-(2-Phenylethyl)-4-piperidinol | HCID 77055 | — |
| Product | HCID 20459841 | HCID 20459841 | 91.3% |
Reaction Steps
Similarly as in Reference Example 1, 5.40 g of 1-phenethyl-4-hydroxypiperidine and 2.65 g of diketene were reacted. The reaction mixture was concentrated, and then purified by silica gel column chromatography (eluent:chloroform:methanol=9:1 v/v), to obtain 6.95 g of acetoacetic acid-N-phenethyl-4-piperidinyl ester (yield: 91.3%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04448964 |
| Source dataset | uspto-grants-1984_05 |
| ORD ID | ord-18436aef51b748d4bca478f3a2841652 |
| Source note | uspto-grants-1984_05 |