Diketene → HCID 20459844, compound

HRID 544253Notes

Reaction equation

HRID 544253 reaction equation
[C:1]([N:9]1[CH2:14][CH2:13][CH:12]([OH:15])[CH2:11][CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:16]=[C:17]1[O:21][C:19](=[O:20])[CH2:18]1>>[C:1]([N:9]1[CH2:14][CH2:13][CH:12]([O:15][C:19](=[O:20])[CH2:18][C:17]([CH3:16])=[O:21])[CH2:11][CH2:10]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 12661DiketeneHCID 9877704N-benzoyl-4-hydroxypiperidine

Product 1

HCID 20459844HCID 20459844, compound

Procedure

Then, 8.16 g of the 1-benzoyl-4-hydroxypiperidine and 3.53 g of diketene were reacted similarly as in Reference Example 1, and the reaction mixture was concentrated to obtain 12.0 g of almost pure oily acetoacetic acid-N-benzoyl-4-piperidinyl ester on thin layer chromatography. This was used directly in the reaction of Example 3.

Workup

  1. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-a6432d95120e4e53b8c2fc2d322ba6d0
Source dataset
uspto-grants-1984_05
Patent number
US04448964

Reaction notes

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