HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Chloride → 1-Benzylpiperidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Chloride | HCID 7503 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Piperidine-3-ol hydrochloride | HCID 2723962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Benzylpiperidin-3-ol | HCID 85773 | 56.9% |
Reaction Steps
A mixture of 15.0 g of 3-hydroxypiperidine hydrochloride, 13.8 g of benzyl chloride, 22.1 g of triethylamine and 120 ml of toluene was stirred at reflux for 4 hours. The reaction mixture was filtered, and the filtrate was concentrated and distilled under reduced pressure to obtain 11.8 g of 1-benzyl-3-hydroxypiperidine (yield: 56.9%). b.p.: 125°-126° C./3.5 mmHg
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04448964 |
| Source dataset | uspto-grants-1984_05 |
| ORD ID | ord-4a4ba222e85146b9a3e0990b3198c195 |
| Source note | uspto-grants-1984_05 |