Water → Isobutyric Acid

HRID 544262Notes

Reaction equation

HRID 544262 reaction equation
[C:1]([OH:6])(=[O:5])[CH:2]([CH3:4])[CH3:3].[OH2:7]>>[C:1]([OH:6])(=[O:5])[CH:2]([CH3:4])[CH3:3].[OH:7][C:2]([CH3:4])([CH3:3])[C:1]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 962WaterHCID 6590Isobutyric Acid

Product 2

HCID 6590Isobutyric AcidHCID 116712-Hydroxyisobutyric acid

Procedure

In Examples 1-10 which follow in Table form, an aqueous solution of isobutyric acid (IBA) was prepared by weighing the desired quantities of the isobutyric acid and water into a 500 ml round bottom glass reaction flask equipped with a mechanical stirrer, a thermometer and reflux condenser. A molar equivalent quantity of a TlX3 salt compound, calculated according to the above-mentioned reaction formula, was added and the reaction mixture heated on an oil bath to the desired temperature with stirring for the desired time. The contents of the flask were then cooled and filtered to remove any insoluble TlX. The filtrate was titrated for unconverted Tl+3 and the product α-hydroxyisobutyric acid (α HIBA) determined by high pressure liquid chromatographic analysis. The α-hydroxyisobutyric acid yield (mol percent) is calculated as follows: ##EQU1##

Workup

  1. customequipped with a mechanical stirrer
  2. temperaturea thermometer and reflux condenser
  3. additionwas added
  4. temperaturethe reaction mixture heated on an oil bath to the desired temperature
  5. temperatureThe contents of the flask were then cooled
  6. filtrationfiltered
  7. customto remove any insoluble TlX

Sources & evidence

ORD record
ord-7a42b128b71c4709a5dab4a3c1d35336
Source dataset
uspto-grants-1984_05
Patent number
US04448985

Reaction notes

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