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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 544268Generated: October 25, 2026

Phosphorus oxychloride → HCID 20460009, compound

https://huagongshe.com/reaction/544268

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhosphorus oxychlorideHCID 24813—
ReactantSodium borohydrideHCID 4311764—
ReactantHCID 12838393HCID 12838393—
Reactant1-(m-Methoxyphenyl)-2-hydroxycyclohexane-1-propionitrileHCID 20460002—
Reactant1-(m-Methoxyphenyl)-2-oxo-cyclohexane-propionitrileHCID 20460008—
SolventPyridineHCID 1049—
ProductHCID 20460009HCID 20460009—

Reaction Steps

By reducing 1-(m-methoxyphenyl)-2-oxo-cyclohexane-propionitrile with sodium borohydride and subsequently dehydrating the resulting 1-(m-methoxyphenyl)-2-hydroxycyclohexane-1-propionitrile with phosphorus oxychloride in pyridine in analogy to the preparation of 1-(m-methoxyphenyl)-2-cyclohexene-1-acetonitrile described in Example 1, there is obtained 1-(m-methoxyphenyl)-2-cyclohexene-1-propionitrile in the form of a pale yellowish oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04448991
Source datasetuspto-grants-1984_05
ORD IDord-626384479d06429d913706bb25191e53
Source noteuspto-grants-1984_05