HCID 12838404, compound → HCID 12838397, compound

HRID 544274Notes

Reaction equation

HRID 544274 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:14][CH2:13][CH2:12][CH2:11][C:10]2=[O:15])[CH:6]=[CH:7][CH:8]=1.[H][H]>C(O)C.[Pt]=O>[OH:15][CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][C:9]1([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=1)[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18]

Participants

5

Reactant 2

HCID 12838404HCID 12838404, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 12838397HCID 12838397, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

200 g of ethyl 1-(m-methoxyphenyl)-2-oxo-cyclohexaneacetate are dissolved in 2000 ml of ethanol, and after treatment with 20 g of platinum oxide, the mixture is reduced with hydrogen at 50° C. and 50 bar. After separation of the catalyst, the solvent is removed by distillation, and there is obtained ethyl 2-hydroxy-1-(m-methoxyphenyl)-cyclohexaneacetate in the form of a light yellow oil.

Workup

  1. customAfter separation of the catalyst
  2. customthe solvent is removed by distillation

Sources & evidence

ORD record
ord-af408766cdba4a1e8ea5d82421382731
Source dataset
uspto-grants-1984_05
Patent number
US04448991

Reaction notes

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