反应详情

In this example, 1.5 g of 1-methyl-3-phenylpropylamine and 1.8 g of 1-(2-cyanophenoxy)-2,3-epoxypropane are refluxed for 1.5 hours in 50 ml of99.5% ethanol. After completion of the reaction, the reaction solution is concentrated under reduced pressure. The residue is then charged on a column packed with silica gel and the elution is carried out with methanol. The main fraction of the eluate is concentrated under reduced pressure. Then, the residue is recrystallized from 200 ml of n-hexane to obtain 20 g of 1-(2-cyanophenoxy)-3-(1-methyl-3-phenylpropylamino)-2-propanol as crystals. (Yield: 62%)

1. customAfter completion of the reaction
2. concentrationthe reaction solution is concentrated under reduced pressure
3. additionThe residue is then charged on a column
4. washthe elution
5. concentrationThe main fraction of the eluate is concentrated under reduced pressure
6. customThen, the residue is recrystallized from 200 ml of n-hexane