Bromine → HCID 942132, compound

HRID 544369Notes

Reaction equation

HRID 544369 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]2[O:6][C:7]([C:10](=[O:12])[CH3:11])=[C:8]([CH3:9])[C:4]=2[CH:3]=1.[Br:15]Br>C(O)(=O)C>[F:1][C:2]1[CH:14]=[CH:13][C:5]2[O:6][C:7]([C:10](=[O:12])[CH2:11][Br:15])=[C:8]([CH3:9])[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 24408Bromine2×HCID 203892031-(5-Fluoro-3-methyl-1-benzofuran-2-yl)ethan-1-one

Product 1

HCID 942132HCID 942132, compoundYield 70.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

In this Reference Example, 38.4 g of 5-fluoro-3-methyl-2-acetylbenzo [b] furan is dissolved in 200 ml of acetic acid and 32.0 g of bromine is addeddropwise thereto at room temperature. The mixture solution is then stirred for 30 minutes at room temperature, whereby the color of bromine disappears and crystals are deposited from the solution. Then, the solution is filtered to obtain 38.0 g of 5-fluoro-3-methyl-2-(α-bromoacetyl) benzo [b] furan as crystals. (Yield: 70%). Melting point of the desired compound recrystallized from ethanol is 120°-123° C.

Workup

  1. customat room temperature
  2. filtrationThen, the solution is filtered

Sources & evidence

ORD record
ord-04d5d55532924de79abdb8b7d24e937c
Source dataset
uspto-grants-1984_05
Patent number
US04450115

Reaction notes

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