HCID 943226, compound → HCID 70511232, compound

HRID 544371Notes

Reaction equation

HRID 544371 reaction equation
C(OC([N:8]1[CH2:23][CH2:22][CH2:21][C@H:9]1[C:10]([NH:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:11])=O)(C)(C)C.C(OCC)(=O)C.[ClH:30]>CCOCC>[ClH:30].[C:15]1([CH2:14][CH2:13][NH:12][C:10](=[O:11])[C@@H:9]2[CH2:21][CH2:22][CH2:23][NH:8]2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 943226HCID 943226, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 70511232HCID 70511232, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 1-(tert-butyloxycarbonyl)-N-(2-phenylethyl)-L-prolinamide (2.46 g.) in ethyl acetate-hydrogen chloride (3.9 N, 30 ml.) was stirred for 20 minutes at room temperature, then diluted with ether (to about 200 ml.). The solvents were decanted from the resulting gum, which was triturated with ether, affording crystalline N-(2-phenylethyl)-L-prolinamide hydrochloride (1.91 g., m.r. 147°-150° ).

Workup

  1. customThe solvents were decanted from the resulting gum, which
  2. customwas triturated with ether

Sources & evidence

ORD record
ord-a2711669812d498bbaf9f47f16d2e2f7
Source dataset
uspto-grants-1984_05
Patent number
US04450155

Reaction notes

Loading…