Hydrogen chloride-ethyl acetate → HCID 70512540, compound

HRID 544375Notes

Reaction equation

HRID 544375 reaction equation
C(OC([N:8]1[CH2:25][CH2:24][CH2:23][C@H:9]1[C:10]([N:12]([CH3:22])[CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:11])=O)(C)(C)C.C(OCC)(=O)C.[ClH:32]>>[ClH:32].[CH3:22][N:12]([CH2:13][CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[C:10](=[O:11])[C@@H:9]1[CH2:23][CH2:24][CH2:25][NH:8]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 52609464HCID 52609464, compound

Product 1

HCID 70512540HCID 70512540, compound

Procedure

A solution of 1-(tert-butyloxycarbonyl)-N-methyl-N-(3-phenylpropyl)-L-prolinamide in ethyl acetate-hydrogen chloride (3,9 N, 30 ml.) was stirred at room temperature for one hour, then concentrated, affording N-methyl-N-(3-phenylpropyl)-L-prolinamide hydrochloride as a syrup (2.4 g.).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-efb7370ba7f94287a23bbe50d7f35ddb
Source dataset
uspto-grants-1984_05
Patent number
US04450155

Reaction notes

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