Methyl iodide → HCID 20458824, compound

Participants

Reaction Conditions

Reaction Steps

6.0 g (0.041 mol) of 2,2-dimethyl-thiazolidine-4-thione are added cautiously to a suspension of 1.0 g (0.041 mol) of oil-free sodium hydridein 20 ml of absolute dimethylformamide. After completion of the evolution of hydrogen, the mixture is heated briefly to 50° C., then cooled to 0° C. and 2.6 ml (0.042 mol) of methyl iodide are added dropwisethereto. After removing the ice-bath the mixture is stirred for an additional 3 hours, treated with water and extracted twice with methylene chloride. The organic extracts are subsequently combined, washed three times with 100 ml of water each time, dried over anhydrous sodium sulfate and evaporated at 40° C. under reduced pressure to yield crude 2,2-dimethyl-4-methylthio-3-thiazoline.

Provenance & Evidence