反应详情

温度

100 °C

To 3.1 g (0.02 mole) of 4-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine were added 4.7 g (0.05 mole) of aniline and about 10 ml of ethanol; the mixture was then heated at 100° C. for about 10 minutes; the mixture quickly became a solution and then soon produced crystals. The mixture was then heated for a further 5 minutes, after which it was allowed to cool. The crystals produced were collected by filtration and then recrystallised from ethanol, to give 2.9 g (yield 59%) of the desiredCompound No. 2, in the form of yellow needles melting at 220° C. (with decomposition).

1. temperatureThe mixture was then heated for a further 5 minutes
2. temperatureto cool
3. customThe crystals produced
4. filtrationwere collected by filtration
5. customrecrystallised from ethanol
6. customto give 2.9 g (yield 59%) of the desiredCompound No