4,5-Dihydro-2-thiazolamine → HCID 178479724, compound

HRID 544397Notes

Reaction equation

HRID 544397 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([O:14]CC)=O)=[C:5]2[OH:17].[NH2:18][C:19]1[S:20][CH2:21][CH2:22][N:23]=1>>[ClH:1].[S:20]1[CH2:21][CH2:22][N:23]=[C:19]1[NH:18][C:12]([C:6]1[CH:7]=[N:8][C:9]2[C:4]([C:5]=1[OH:17])=[CH:3][C:2]([Cl:1])=[CH:11][CH:10]=2)=[O:14]

Participants

3

Reactant 2

HCID 156894,5-Dihydro-2-thiazolamineHCID 178469539HCID 178469539, compound

Product 1

HCID 178479724HCID 178479724, compound

Procedure

Using the procedure of Example 2, ethyl 6-chloro-4-hydroxy-3-quinoline-carboxylate and 2-amino-thiazoline were reacted at reflux for 48 hours and the product was crystallized from acetic acid to obtain N-(4,5-dihydro-thiazol-2-yl)-6-chloro-4-hydroxy-3-quinoline-carboxamide hydrochloride melting at >260° C.

Workup

  1. customwere reacted
  2. temperatureat reflux for 48 hours
  3. customthe product was crystallized from acetic acid

Sources & evidence

ORD record
ord-dfa610de04114d8abc62d5c81017b28a
Source dataset
uspto-grants-1984_05
Patent number
US04450166

Reaction notes

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