HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (ethoxymethylene)malonate → Ethyl 4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | Diphenyl Ether | HCID 7583 | — |
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Product | Ethyl 4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylate | HCID 178469538 | — |
Reaction Steps
Using the procedure of Example 2, ethyl ethoxymethylene malonate and 4-trifluoromethyl-aniline were reacted and treated with phenyl oxide to obtain ethyl 6-trifluoromethyl-4-hydroxy-3-quinoline-carboxylate melting at >260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04450166 |
| Source dataset | uspto-grants-1984_05 |
| ORD ID | ord-d6fb43e1ceb542bca88b50cee5a7d6f4 |
| Source note | uspto-grants-1984_05 |