Triethylamine → HCID 13040912, compound

Participants

Reaction Steps

A mixture of 5 gm (0.02 mole of methyl 3-[4-(2,3-epoxypropoxy)phenyl]propionate, 3 gm (0.02 mole) of ethyl 3-aminopropionate hydrochloride and 2.8 ml (0.02 mole) of triethylamine in25 mL of isopropanol was heated to reflux for 4 hours. The reaction medium was then cooled and the triethylamine hydrochloride side-product which crystallized was removed by filtration. The mother liquor was then evaporated under reduced pressure and the resulting residue taken up in ethanol and treated with ethereal HCl to provide 1 gm (12%) as a crystalline solid: mp 110°-111°. The NMR spectrum was consistent with the assigned structure and the elemental analysis was consistent with the formula C18H28NO6Cl.

Provenance & Evidence