反应详情

温度

40 °C

40 g of manganese dioxide were added to a solution of 10 g of (2-phenoxy-5-thiazolyl)-methanol in 250 ml of benzene and the mixture was stirred at 40° C. for 5 hours and was filtered. The filtrate was evaporated to dryness and the residue was chromatographed over silica gel.Elution with a 7-3 methylene chloride-ethyl acetate mixture yielded 7.7 g of (2-phenoxy-5-thiazolyl)-methanal melting at 50° C.

1. filtrationwas filtered
2. customThe filtrate was evaporated to dryness
3. customthe residue was chromatographed over silica gel
4. washElution with a 7-3 methylene chloride-ethyl acetate mixture