反应详情

温度

60 °C

19.1 g of manganese dioxide were added to a solution of 4.6 g of (2-phenoxy-4-thiazolyl)-methanol in 100 ml of benzene and the mixture was stirred at 60° C. for 3 hours and was filtered. The filtrate was evaporated to dryness under reduced pressure and the residue was chromatographed over silica gel. Elution with an 8-2 methylene chloride-ethyl acetate mixture yielded 2.6 g of (2-phenoxy-4-thiazolyl)-methanal melting at 63° C.

1. filtrationwas filtered
2. customThe filtrate was evaporated to dryness under reduced pressure
3. customthe residue was chromatographed over silica gel
4. washElution with an 8-2 methylene chloride-ethyl acetate mixture