HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 8-(Benzyloxy)-2-(chloromethyl)imidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | [8-(Benzyloxy)imidazo[1,2-a]pyridin-2-yl]methanol | HCID 20458946 | — |
| Product | 8-(Benzyloxy)-2-(chloromethyl)imidazo[1,2-a]pyridine | HCID 20459003 | — |
Reaction Steps
A mixture of 8-benzyloxy-2-hydroxymethylimidazo[1,2-a]pyridine (2 g) and phosphorylchloride (10 ml) was heated on a steam bath for 1 hr. Excess phosphoryl chloride was distilled off in vacuo, the solid residue triturated with acetonitrile and the mixture filtered to give the title product as the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04450164 |
| Source dataset | uspto-grants-1984_05 |
| ORD ID | ord-ae148568f6294f2fbb8f6fff8a9ff9cb |
| Source note | uspto-grants-1984_05 |