Sodium Cyanide → HCID 20458974, compound

Participants

Reaction Steps

A mixture of 1.79 g 8-benzyloxy-2-chloromethylimidazo[1,2-a]pyridine, 0.90 g sodium cyanide, and 15 ml dimethylformamide was heated on a steam bath for 1.5 hr. The mixture was cooled and evaporated in vacuo, the residue was taken up in chloroform (50 ml) and filtered through a pad of silica gel, the filtrate was evaporated in vacuo, and the residue recrystallized from acetonitrile to give the title compound (m.p. 148°-150°C.).

Provenance & Evidence