Benzonitrile, 4-isothiocyanato- → N-(4-Cyanophenyl)-4-(pyrazin-2-yl)piperazine-1-carbothioamide

Participants

Reaction Steps

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 45 ml. of anhydrous ether is added a slurry of 4.8 g. of p-cyanophenyl isothiocyanate in 45 ml. of anhydrous ether, dropwise over 10 minutes. Themixture is stirred for 30 minutes and the resulting solid collected. This solid is dissolved in a mixture of 200 ml. of benzene and 200 ml. of ethanol and then cooled. The resulting solid is collected giving 6.95 g. of the desired product, m.p. 208°-210° C.

Provenance & Evidence