Cyclohexyl isothiocyanate → N-Cyclohexyl-4-(pyrazin-2-yl)piperazine-1-carbothioamide

Participants

Reaction Steps

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added dropwise a solution of 4.2 g. of cyclohexyl isothiocyanate in 50 ml. of anhydrous ether over 5 minutes. The mixture isstirred for 35 minutes and the resulting solid is collected and recrystallized from 50 ml. of ethanol, giving 7.58 g. of the desired product, m.p. 176°-178° C.

Provenance & Evidence