tert-Butyl isothiocyanate → N-tert-Butyl-4-(pyrazin-2-yl)piperazine-1-carbothioamide

HRID 544492Notes

Reaction equation

HRID 544492 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[C:13]([N:17]=[C:18]=[S:19])([CH3:16])([CH3:15])[CH3:14]>CCOCC>[C:13]([NH:17][C:18]([N:10]1[CH2:9][CH2:8][N:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)[CH2:12][CH2:11]1)=[S:19])([CH3:16])([CH3:15])[CH3:14]

Participants

4

Reactant 2

HCID 11544tert-Butyl isothiocyanateHCID 27346391-Piperazinylpyrazine

Product 1

HCID 13318696N-tert-Butyl-4-(pyrazin-2-yl)piperazine-1-carbothioamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added a solution of 3.45 g. of tert-butyl isothiocyanate in 50 ml. of anhydrous ether. The mixture is stirred for 30minutes and the resulting solid is collected and recrystallized from 50 ml.of ethanol, giving 5.85 g. of the desired product as white crystals, m.p. 153°-156° C.

Workup

  1. customthe resulting solid is collected
  2. customrecrystallized from 50 ml
  3. customof ethanol, giving 5.85 g

Sources & evidence

ORD record
ord-a597b8511d76413fa3f7b9154a995282
Source dataset
uspto-grants-1984_05
Patent number
US04450272

Reaction notes

Loading…