Carbon Dioxide → HCID 57034955, compound

Participants

Reaction Conditions

Reaction Steps

320 ml of concentrated sulphuric acid and 94 ml of water were added to 266.3 g of 1-cyano-1-(3-trifluoromethylphenyl)-3-(1,2,4-triazol-l-yl)-propanone hydrochloride, and the mixture was heated at 100° C. for 1.5 hours. After the vigorous evolution of CO2 had ended, the mixture was allowed to cool, and 940 ml of water were added. After a short time at from 0° to 20° C., the sulphate of the desired end product crystallized out. This was suspended in water, and the suspension was adjusted to a pH value of 7-8 with sodium bicarbonate solution. The resulting crystalline precipitate was filtered off under suction, dissolved in chloroform, dried over sodium sulphate and concentrated. 131.3 g (72% of theory) of 1-(3-trifluoromethylphenyl)-3-(1,2,4-triazol-l-yl)-propanone of melting point 85° to 87° C. were obtained. ##STR8##

Provenance & Evidence