Dimethylamine → 2-Amino-3-dimethylamino-6-(p-fluorophenyl)-5-oxo-2,5-dihydro-1,2,4-triazine

Participants

Reaction Steps

2-Amino-3-methylthio-6-(p-fluorophenyl)-5-oxo-2,5-dihydro-1,2,4-triazine (1.0 g) was added to a mixture of an aqueous solution of 40% dimethylamine (5 ml) and acetonitrile (10 ml), and the resultant mixture was heated under reflux for 1 hour. After completion of the reaction, the resultant mixture was evaporated to dryness under reduced pressure to give a crude product. Recrystallization of the crude product from acetone gave 0.7 g of 2-amino-3-dimethylamino-6-(p-fluorophenyl)-5-oxo-2,5-dihydro-1,2,4-triazine in 53% yield. M.P., 212° C.

Provenance & Evidence