Dimethylamine → HCID 15587001, compound

HRID 544531Notes

Reaction equation

HRID 544531 reaction equation
[NH2:1][N:2]1[C:7](SC)=[N:6][C:5](=[O:10])[C:4]([C:11]([CH3:14])([CH3:13])[CH3:12])=[N:3]1.[CH3:15][NH:16][CH3:17]>N1C=CC=CC=1>[NH2:1][N:2]1[C:7]([N:16]([CH3:17])[CH3:15])=[N:6][C:5](=[O:10])[C:4]([C:11]([CH3:14])([CH3:13])[CH3:12])=[N:3]1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 131633962-Amino-6-tert-butyl-3-(methylsulfanyl)-1,2,4-triazin-5(2H)-one

Product 1

HCID 15587001HCID 15587001, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-Amino-3-methylthio-6-t-butyl-5-oxo-2,5-dihydro-1,2,4-triazine (1.0 g) was added to a mixture of a 40% aqueous solution of dimethylamine (5 ml) and pyridine (10 ml), and the resulting mixture was heated with reflux for 5 hours. After the reaction was completed, the reaction mixture was evaporated to dryness under reduced pressure to give a crude product. Recrystallization of the crude product from acetone gave 0.8 g of 2-amino-3-dimethylamino-6-t-butyl-5-oxo-2,5-dihydro-1,2,4-triazine in 81% yield. M.P. 168°-169° C.

Workup

  1. temperaturethe resulting mixture was heated
  2. temperaturewith reflux for 5 hours
  3. customthe reaction mixture was evaporated to dryness under reduced pressure
  4. customto give a crude product
  5. customRecrystallization of the crude product from acetone

Sources & evidence

ORD record
ord-4593113e3fe64c7498603a7d1b319d6c
Source dataset
uspto-grants-1984_05
Patent number
US04451283

Reaction notes

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