Ethanol → HCID 13309031, compound

Participants

Reaction Steps

A solution of 1.0 g. of 3-(2-chloroethyl)-2,6-dichloro-3,4-dihydroquinazolin-4-one in 50 ml. of ethanol is combined with a solution of 0.62 g. of allylamine in 10 ml of dimethylacetamide and the resulting mixture heated to reflux with dimethylacetamide being added as required to dissolve any remaining solid starting material. After heating at reflux for about 5 hours the resulting reaction mixture is allowed to cool, the mixture stripped down to a dimethylacetamide slurry and pentane added. A white solid form which dissolves upon addition of water after which the organic layer is dried and concentrated in vacuo to a solid residue which is washed with pentane to obtain 1-allyl-7-chloro-2,3-dihydro-imidazo[2,1-b]quinazolin-5(1H)-one, m.p. 91°-93° C.

Provenance & Evidence