HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malononitrile → 3-Cyano-4,6-dimethyl-2-hydroxypyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malononitrile | HCID 8010 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Acetylacetone | HCID 31261 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Cyano-4,6-dimethyl-2-hydroxypyridine | HCID 69856 | — |
Reaction Steps
Bergel et al [British Pat. No. 553,097, accepted May 7, 1943] shows the reaction of acetylacetone with malononitrile in ethanol in the presence of piperidine to produce 3-cyano-4,6-dimethyl-2(1H)-pyridinone (named as its 5-cyano-2,4-dimethyl-6-hydroxypyridine tautomer).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04451469 |
| Source dataset | uspto-grants-1984_05 |
| ORD ID | ord-6bd5c4b130c94257a2d7a116b9eb8dd2 |
| Source note | uspto-grants-1984_05 |