HCID 13188003, compound → HCID 13188004, compound

Participants

Reaction Steps

Sodium thioacetate (235 mg) was added to an ice-cooled, stirred solution of 1 g of 2-bromomethyl-3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-4(3H)-quinazolinone in 4 ml of dimethylformamide. After stirring for an additional 30 minutes, the mixture was poured into ice-water. The resulting precipitate was filtered off, washed with water, and dried in vacuo. The crude product was chromatographed on a column of silica gel using 5% ethyl acetate in benzene as an eluent to give 619 mg (yield, 62.5%) of 2-(acetylmercaptomethyl)-3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-4(3H)-quinazolinone melting at 103°-105° C. (recrystallized from methanol).

Provenance & Evidence