Ethyl Acetate → HCID 57101162, compound

Participants

Reaction Steps

The above obtained amide ester (step b) was heated with lithium aluminum hydride (1 g) in tetrahydrofuran (50 ml) at reflux for 31/2 hours. After cooling the reaction mixture, the excess reducing agent was decomposed by adding ethyl acetate, then water, and then dilute potassium bicarbonate solution until the pH was ca. 8.5. The inorganic salts were filtered off, and the filter cake washed with hot tetrahydrofuran. The filtrate was evaporated to dryness and the residue washed thoroughly with water and air dried. Recrystallization from methanol yielded 700 mg of the title compound whch melted at 173°-174°.

Provenance & Evidence