HCID 21824976, compound → HCID 13094300, compound

Participants

Reaction Steps

A solution consisting of 1-(2-methyl-3-indolyl)-1-(3-pyridyl)ethylene (9.37 g.), prepared according to the procedure described in the Journal of Heterocyclic Chemistry, Vol. 9, p. 833 (1972), dissolved in ethanol (200 ml.) was hydrogenated at 2.5 atmospheric pressure in the presence of 10% palladium-on-charcoal catalyst. The resulting reaction mixture was then filtered to remove the catalyst and the filtrate subsequently evaporated under reduced pressure to afford a residue. Crystallization of the latter material from an ethyl acetate/petroleum ether (b.p. 60°-80° C.) mixture then gave pure 2-methyl-3-[1-(3-pyridyl)ethyl]indole (yield, 5.74 g.), m.p. 139°-141° C.

Provenance & Evidence