HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl isothiocyanate → 1-(4-Hydroxybutyl)-3-(3-benzoylthioureido)pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl isothiocyanate | HCID 68284 | — |
| Reactant | 4-(3-amino-1H-pyrazol-1-yl)butan-1-ol | HCID 20451299 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-(4-Hydroxybutyl)-3-(3-benzoylthioureido)pyrazole | HCID 53785858 | 30% |
Reaction Steps
A mixture of 3-amino-1-(4-hydroxybutyl)pyrazole (0.966 g.) and benzoylisothiocyanate (1.0 g.) in acetone (30 ml.) was stirred at room temperature for 18 hours. The solvent was evaporated and the residue purified by column chromatography on silica gel using EtOAc as eluant to give 1-(4-hydroxybutyl)-3-(3-benzoylthioureido)pyrazole (30% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04451463 |
| Source dataset | uspto-grants-1984_05 |
| ORD ID | ord-56884fdf823b42faa8e14a07aff955d0 |
| Source note | uspto-grants-1984_05 |