HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl Isothiocyanate → 1-(4-Hydroxybutyl)-3-(3-phenylthioureido)pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl Isothiocyanate | HCID 7673 | — |
| Reactant | 4-(3-amino-1H-pyrazol-1-yl)butan-1-ol | HCID 20451299 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(4-Hydroxybutyl)-3-(3-phenylthioureido)pyrazole | HCID 54015027 | 29% |
Reaction Steps
To a solution of 3-amino-1-(4-hydroxybutyl)pyrazole (1.0 g.) in dry acetonitrile (3 ml.) was slowly added phenylisothiocyanate (0.95 g.) and the mixture was stirred at room temperature for 17 hours. The solvent was evaporated and the residue purified by column chromatography on silica gel using EtOAc as eluant to give 1-(4-hydroxybutyl)-3-(3-phenylthioureido)pyrazole (0.54 g.; 29%), m.p. 112°-117°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04451463 |
| Source dataset | uspto-grants-1984_05 |
| ORD ID | ord-bb1c2e5ff6a449c18db79a5c178c6732 |
| Source note | uspto-grants-1984_05 |