Hydrochloric Acid → HCID 20458252, compound

Participants

Reaction Steps

A solution of 2-(3-benzyloxypropyl)-4-[2-(2,2,2-trifluoroethyl)guanidino]pyrimidine (3.7 g.) in EtOH (75 ml.) containing concentrated aqueous HCl (1 ml.) was hydrogenated over 5% w/w palladium on carbon (1 g.). The filtrate was evaporated and the residue was partitioned between dilute aqueous NaOH and EtOAc. The EtOAc solution was washed with brine, dried and evaporated and the residue was crystallised from EtOAc to give 2-(3-hydroxypropyl)-4-[2-(2,2,2-trifluoroethyl)guanidino]pyrimidine (0.2 g.), m.p. 136°-138°.

Provenance & Evidence